Effect of Ubiquinol(Reduced form of coenzyme Q10) on chronic fatigue syndrome

Kaneka Corporation(headquarters : Osaka, Japan; President: Mr. Kimikazu Sugawara) confirmed the effect of the reduced form coenzyme Q10(hereafter, Ubiquinol) in improving the chronic fatigue syndrome showing long-lasting fatigue, tiredness, etc. with unknown cause. This research was conducted in collaboration with Special Appointment Prof. Yasuyoshi Watanabe of Osaka City University Graduate School of Medicine (Osaka, Japan; President and Chairperson of the board of directors: Dr. Yoshiki Nishizawa)(holding Director of RIKEN Center for Molecular Imaging Science concurrently).

These results were presented at the 7th conference of the International Coenzyme Q10 Association held at Seville, Spain on November 8-11, 2012.

Twenty patients (5 males, 15 females, average age: 36.8 years old) with chronic fatigue syndrome were supplemented with Ubiquinol (150mg/day) for 2 months. Fatigue, sleep quality and depression, oxidative stress and anti-oxidative activities and arithmetic tasks were evaluated before and after 2 months of the supplementation.

As a result, depression symptoms, sleep duration and the performance in the arithmetic task were improved after the supplementation, and these improvements were dependent on increases in plasma coenzyme Q10 levels. And the increases in plasma coenzyme Q10 levels correlated with decreases in plasma oxidative stress. It is noteworthy that decreases in oxidative stress and in energy production are related to the mechanism on chronic heart failure syndrome.